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FLASH GENE
Symbol LMO1 contributors: shn - updated : 01-06-2011
HGNC name LIM domain only 1 (rhombotin 1)
HGNC id 6641
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
in acute lymphoblastic leukemia (T ALL)with translocation t(11;14)p15;q11),and a LMO1/LDB1 interaction, likely involved in tumorigenesis
Susceptibility
  • to neuroblastoma
  • Variant & Polymorphism other common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma (
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS