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FLASH GENE

Symbol

LMO1

contributors: shn - updated : 01-06-2011

HGNC name	LIM domain only 1 (rhombotin 1)
HGNC id	6641

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two N-terminal cysteine-rich LIM/double zinc finger motifs (LIM domains)

HOMOLOGY

interspecies	ortholog to Lmo1, Mus musculus
	ortholog to Lmo1, Rattus norvegicus
	ortholog to LMO1, Pan troglodytes
	ortholog to lmo1, Danio rerio

intraspecies

paralog to LMO2, LMO3 and LMO4

Homologene

FAMILY

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus

basic FUNCTION	having transcription factor activity
	may be involved in gene regulation cells potentially by direct DNA binding or by binding to other transcription factors
	intertwining LIM-only factor involved in protein-DNA oligomeric complexes
	takes potentially part in a Hox paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

	TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis

a component

INTERACTION

DNA

binding

RNA

small molecule

metal binding,

protein	leukemogenic bHLH proteins TAL1, TAL2 and LYL1 (
	LIM-binding protein LDB1 (
	embryonic neuronal-specific basic-helix-loop-helix protein, HEN1 (
	LMO1 and SHOX2, are ARX targets (mutations in the ARX homeodomain disrupt repression of LMO1 and SHOX2, direct targets of ARX transcription repression)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     in acute lymphoblastic leukemia (T ALL)with translocation t(11;14)p15;q11),and a LMO1/LDB1 interaction, likely involved in tumorigenesis

Susceptibility

to neuroblastoma

Variant & Polymorphism other	common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma (

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS