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FLASH GENE
Symbol CFL2 contributors: SGE/npt - updated : 01-02-2010
HGNC name cofilin 2 (muscle)
HGNC id 1875
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one ADF-H domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Cfl2 (99.4pc)
    homolog to rattus Cfl2 (99.4pc)
    Homologene
    FAMILY
  • actin-binding protein ADF family
    • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • actin-binding protein, depolymerization factor of F-actin to G-actin
  • playing a role in normal muscle function and regeneration
  • interfering with immunological synapse formation and T-cell activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with CSRP3 that is directly invovled in sarcomere dysfunction and disase, due to its role in regulating CFL2-dependent F actin depolymerization (Papalouka 2009)
  • major component of the intranuclear and cytoplasmic actin rods
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other phosphorylation of Ser24 may prevent recognition of the nuclear localization signal
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • activated in CD4 T cells of HIV patients, aberrant activation that may also lead to abnormalities in T cells migration and activation that could contribute to viral pathogenesis (Wu 2008)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS