Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CFL2 contributors: SGE/npt - updated : 01-02-2010
HGNC name cofilin 2 (muscle)
HGNC id 1875
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Reproductivemale systemprostate  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one ADF-H domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Cfl2 (99.4pc)
    homolog to rattus Cfl2 (99.4pc)
    Homologene
    FAMILY
  • actin-binding protein ADF family
    • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • actin-binding protein, depolymerization factor of F-actin to G-actin
  • playing a role in normal muscle function and regeneration
  • interfering with immunological synapse formation and T-cell activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with CSRP3 that is directly invovled in sarcomere dysfunction and disase, due to its role in regulating CFL2-dependent F actin depolymerization (Papalouka 2009)
  • major component of the intranuclear and cytoplasmic actin rods
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other phosphorylation of Ser24 may prevent recognition of the nuclear localization signal
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • activated in CD4 T cells of HIV patients, aberrant activation that may also lead to abnormalities in T cells migration and activation that could contribute to viral pathogenesis (Wu 2008)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS