Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CCL3L1

contributors: SGE/npt - updated : 13-07-2010

HGNC name	chemokine (C-C motif) ligand 3-like 1
HGNC id	10628

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to HIV/acquired immunodeficiency syndrome (AIDS)

Variant & Polymorphism other	a low copy number is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility
	lower CCL3L1 gene copy number compared to the population median is associated with chronic hepatitis C (Grünhage 2010)
	CCR5-59029 AG genotype and CCL3L1 gene dose appear to have synergistic or interactive effects and are expected to be involved in the host innate resistance to HIV-1 infection (Rathore 2009)
	copy number of CCL3L1 influences risk of systemic lupus erythaematosus (SLE) and modifies the SLE-influencing effects associated with the CCR5 genotypes (Mamtani 2008)

Candidate gene
Marker
Therapy target	CCL3L1-CCR5 variations may be useful in identifying patients requireng earlier initiation of highly active antiretroviral therapy (Ahuja 2008)

ANIMAL & CELL MODELS