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FLASH GENE
Symbol CCL16 contributors: - updated : 01-04-2006
HGNC name chemokine (C-C motif) ligand 16
HGNC id 10614
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 5.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text with two forms generated through alternative polyadenylation sites,579 and 1503 bp,same product 120 AA (Shoudai)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Digestiveliver   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cysteines conserved among the CC family
  • HIF1 binding site
    • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY intercrine beta family (small inducible cytokine, chemokine beta), CC subfamily
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • lymphocyte and monocyte chemoattractant
  • showing a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other upregulated by IL-10.
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS