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FLASH GENE

Symbol

TXNRD1

contributors: mct - updated : 19-10-2022

HGNC name	thioredoxin reductase 1
HGNC id	12437

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   may be one putative cause for glucocorticoid resistance in alopecia areata, through the impact on intracellular redox system tumoral     --over   in HCC tissues and cells, and tumor with significantly shorter survival time constitutional germinal mutation       in generalized epilepsy

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for the prognosis of patients with HCC
Therapy target
	System Type Disorder Pubmed cancer hemopathy   cysteine depletion serves as a potential therapeutic strategy for overcoming chemotherapy resistance chronic myeloid leukemia (CML)

ANIMAL & CELL MODELS