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FLASH GENE
Symbol TXNRD1 contributors: - updated : 14-06-2007
HGNC name thioredoxin reductase 1
HGNC id 12437
Location 12q23-q24      Physical location : 104.609.558 - 104.744.058
Synonym name
  • selenoprotein thioredoxin reductase 1
  • KM-102-derived reductase-like factor
  • thioredoxin reductase GRIM-12
  • Synonym symbol(s) TXR,TR1,TXNR,TRXR1, TR, GRIM12
    EC.number 1.8.1.9
    DNA
    TYPE functioning gene
    STRUCTURE 63.00 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • Sp1, Oct-1, Sp3 binding sites
  • AU-rich element (ARE)
  • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3923 60 551 - -
  • longest transcript
  • a 15 exons variant
  • containing exon 1a (longer than 1b)
  • encoding for isoform 1
  • - splicing 3813 54 499 - -
  • a 14 exons variant
  • containing exon 1a (longer than 1b)
  • lacking exon 2
  • encoding for the same isoform 2 as variants 3 & 4
  • - splicing 3694 54 499 - -
  • a 15 exons variant
  • containing exon 1b (shorter than 1a)
  • encoding for the same isoform 2 as variants 2 & 4
  • - splicing 3576 54 499 - -
  • a 14 exons variant
  • containing exon 1b (shorter than 1a)
  • lacking exon 2
  • encoding for the same isoform 2 as variants 2 & 3
  • - splicing 3859 70 649 expressed primarily in the testis -
  • encoding for isoform 3
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveesophagus   highly
     liver   moderately
     mouth   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix moderately
     male systemtestis  highly
    Respiratorylung   moderately
     respiratory tracttrachea  predominantly
    Skin/Tegumentskin   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a NADPH-binding domain
  • a FAD-binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee TXNRD1 (99.60 pc)
    homolog to rattus Txnrd1 (90.78 pc)
    homolog to murine Txnrd1 (91.58 pc)
    homolog to chicken TXNRD1 (85.31 pc)
    Homologene
    FAMILY pyridine nucleotide-disulfide oxidoreductase class-1 family
    CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION key enzyme in the regulation of the intracellular redox environment
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FAD
  • NADP
  • protein
    cell & other
    REGULATION
    repressed by estradiol
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may be one putative cause for glucocorticoid resistance in alopecia areata, through the impact on intracellular redox system
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS