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FLASH GENE
Symbol TXNRD1 contributors: - updated : 14-06-2007
HGNC name thioredoxin reductase 1
HGNC id 12437
Location 12q23-q24      Physical location : 104.609.558 - 104.744.058
Synonym name
  • selenoprotein thioredoxin reductase 1
  • KM-102-derived reductase-like factor
  • thioredoxin reductase GRIM-12
  • Synonym symbol(s) TXR,TR1,TXNR,TRXR1, TR, GRIM12
    EC.number 1.8.1.9
    DNA
    TYPE functioning gene
    STRUCTURE 63.00 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • Sp1, Oct-1, Sp3 binding sites
  • AU-rich element (ARE)
  • MAPPING cloned Y linked   status confirmed
    Physical map
    LOC387880 12 similar to 10 KD HEAT SHOCK PROTEIN, MITOCHONDRIAL (HSP10) (10 KD CHAPERONIN) (CPN10) FLJ11259 12q23.3 hypothetical protein FLJ11259 LOC390353 12 similar to ribosomal protein L9 CGI-116 12q23.3 CGI-116 protein Nup37 12q23.3 nucleoporin Nup37 FLJ20641 12q23.3 hypothetical protein FLJ20641 PMCH 12q23.1 pro-melanin-concentrating hormone IGF1 12q23.1 insulin-like growth factor 1 (somatomedin C) PAH 12q23.1 phenylalanine hydroxylase ASCL1 12q23.1 achaete-scute complex-like 1 (Drosophila) FLJ25323 12q23.3 FLJ25323 protein STAB2 12q33.3 stabilin 2 TU12B1-TY 12q22-q23.1 TU12B1-TY protein LOC253724 12q23.3 hypothetical LOC253724 LOC283350 12q23.3 similar to cDNA sequence BC030307 TRA1 12q23.1 tumor rejection antigen (gp96) 1 LOC387881 12 LOC387881 TDG 12q22-24.1 thymine-DNA glycosylase LOC83468 12q gycosyltransferase HCF-2 12q23.3 host cell factor 2 NFYB 12q22-q23 nuclear transcription factor Y, beta LOC390354 12 similar to ribosomal protein L18a; 60S ribosomal protein L18a TXNRD1 12q23-q24 thioredoxin reductase 1 CHST11 12q23.2-q23.3 carbohydrate (chondroitin 4) sulfotransferase 11 DKFZP434K0427 12q24.11 hypothetical protein DKFZp434K0427 LOC121054 12q24.11 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC40397 12q24.11 hypothetical protein MGC40397 FLJ38508 12q24.11 hypothetical protein FLJ38508 KIAA1033 12q24.11 KIAA1033 protein DIP13B 12q24.1 DIP13 beta LOC387882 12 hypothetical gene supported by AJ311377; BC013920 LOC390355 12 similar to dynein, axonemal, heavy chain 11; situs inversus viscerum; dynein, axon, heavy chain 11 LOC245718 12q24.11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein ARK5 12q24.11 AMP-activated protein kinase family member 5 LOC341378 12q24.11 similar to thyroid hormone receptor interactor 11; thyroid receptor interacting protein 11 CKAP4 12q24.11 cytoskeleton-associated protein 4 MGC40368 12q24.11 hypothetical protein MGC40368 RPC2 12q24.11 RNA polymerase III subunit RPC2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3923 60 551 - -
  • longest transcript
  • a 15 exons variant
  • containing exon 1a (longer than 1b)
  • encoding for isoform 1
  • - splicing 3813 54 499 - -
  • a 14 exons variant
  • containing exon 1a (longer than 1b)
  • lacking exon 2
  • encoding for the same isoform 2 as variants 3 & 4
  • - splicing 3694 54 499 - -
  • a 15 exons variant
  • containing exon 1b (shorter than 1a)
  • encoding for the same isoform 2 as variants 2 & 4
  • - splicing 3576 54 499 - -
  • a 14 exons variant
  • containing exon 1b (shorter than 1a)
  • lacking exon 2
  • encoding for the same isoform 2 as variants 2 & 3
  • - splicing 3859 70 649 expressed primarily in the testis -
  • encoding for isoform 3
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveesophagus   highly
     liver   moderately
     mouth   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix moderately
     male systemtestis  highly
    Respiratorylung   moderately
     respiratory tracttrachea  predominantly
    Skin/Tegumentskin   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a NADPH-binding domain
  • a FAD-binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee TXNRD1 (99.60 pc)
    homolog to rattus Txnrd1 (90.78 pc)
    homolog to murine Txnrd1 (91.58 pc)
    homolog to chicken TXNRD1 (85.31 pc)
    Homologene
    FAMILY pyridine nucleotide-disulfide oxidoreductase class-1 family
    CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION key enzyme in the regulation of the intracellular redox environment
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FAD
  • NADP
  • protein
    cell & other
    REGULATION
    repressed by estradiol
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may be one putative cause for glucocorticoid resistance in alopecia areata, through the impact on intracellular redox system
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS