Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

TXNRD1

contributors: - updated : 14-06-2007

HGNC name	thioredoxin reductase 1
HGNC id	12437

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q23-q24      Physical location : 104.609.558 - 104.744.058
Synonym name	selenoprotein thioredoxin reductase 1
	KM-102-derived reductase-like factor
	thioredoxin reductase GRIM-12
Synonym symbol(s)	TXR,TR1,TXNR,TRXR1, TR, GRIM12
EC.number	1.8.1.9

DNA

TYPE	functioning gene
STRUCTURE	63.00 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site
text structure	Sp1, Oct-1, Sp3 binding sites
	AU-rich element (ARE)

MAPPING

cloned

Y

linked

status

confirmed

Physical map

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 3923 variant 1 60 551 - - longest transcript a 15 exons variant containing exon 1a (longer than 1b) encoding for isoform 1 variant 2 - splicing 3813 variant 2 54 499 - - a 14 exons variant containing exon 1a (longer than 1b) lacking exon 2 encoding for the same isoform 2 as variants 3 & 4 variant 3 - splicing 3694 variant 3 54 499 - - a 15 exons variant containing exon 1b (shorter than 1a) encoding for the same isoform 2 as variants 2 & 4 variant 4 - splicing 3576 variant 4 54 499 - - a 14 exons variant containing exon 1b (shorter than 1a) lacking exon 2 encoding for the same isoform 2 as variants 2 & 3 variant 5 - splicing 3859 variant 5 70 649 expressed primarily in the testis - encoding for isoform 3

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive esophagus       highly   liver       moderately   mouth       highly Lymphoid/Immune thymus       highly Nervous brain       moderately Reproductive female system uterus cervix   moderately   male system testis     highly Respiratory lung       moderately   respiratory tract trachea     predominantly Skin/Tegument skin       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a NADPH-binding domain
	a FAD-binding domain

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to chimpanzee TXNRD1 (99.60 pc)
	homolog to rattus Txnrd1 (90.78 pc)
	homolog to murine Txnrd1 (91.58 pc)
	homolog to chicken TXNRD1 (85.31 pc)

Homologene

FAMILY

pyridine nucleotide-disulfide oxidoreductase class-1 family

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

key enzyme in the regulation of the intracellular redox environment

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	FAD
	NADP

protein

cell & other

REGULATION

repressed by

estradiol

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   may be one putative cause for glucocorticoid resistance in alopecia areata, through the impact on intracellular redox system

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS