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FLASH GENE
Symbol NPTX1 contributors: mct - updated : 28-03-2022
HGNC name neuronal pentraxin I
HGNC id 7952
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to rat Np1
Homologene
FAMILY neuronal pentraxin gene family
CATEGORY signaling neurotransmitter
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • mediating the uptake of synaptic material and presynaptic toxins
  • NPTX1 hypermethylation and consequent mRNA changes might be an important molecular mechanism in lung cancer
  • NPTX1 plays a crucial role in promoting metastasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NPTX1 acts in neural induction from human pluripotent stem cells (hPSCs) in part by binding the NODAL receptor cofactor TDGF1, reducing both NODAL and BMP signaling
  • C1QL3 mediates a novel cell-cell adhesion complex involving ADGRB3 and two neuronal pentraxins, NPTX1 and NPTXR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA50
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colon cancer
    constitutional       gain of function
    is rapidly upregulated during neural induction from human pluripotent stem cells (hPSCs)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • acts as a prognostic indicator in gastric cancer
  • potential diagnostic and prognostic biomarker in lung cancer (PMID;
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    NPTX1 suppress the colon cancer cell growth and might serve as a useful potential target for treatment of colon cancer
    ANIMAL & CELL MODELS