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FLASH GENE
Symbol UBE2G1 contributors: mct - updated : 28-09-2011
HGNC name ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)
HGNC id 12482
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved UBC domain of 150 AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
    • HOMOLOGY
    interspecies homolog to C.elegans UBC7
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • catalyzing the covalent attachment of ubiquitin to other proteins
  • may be involved in degradation of muscle-specific proteins
  • modulating the transcriptional activity of progesterone receptor (PR) and glucocorticoid, androgen, and retinoic acid receptors in a hormone-dependent manner
  • playing a possible role in steroid receptor transactivation
  • participating in ERAD
  • UBE2G1 and UBE2G2 cooperate with IL17RB to polyubiquitylate and degrade CDT1 postradiation, an activity that is critical for preventing origin licensing in DNA-damaged cells
    • CELLULAR PROCESS cell cycle
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a complex with UBE1, UBE2E2, UBE2D1, UBE3, CBL ubquitination complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with steroid receptor coactivator 1, SRC-1 (coactivation function is dependent on SRC-1)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS