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FLASH GENE

Symbol

UBE2G1

contributors: mct - updated : 28-09-2011

HGNC name	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)
HGNC id	12482

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.2      Physical location : 4.172.513 - 4.269.969
Synonym name	ubiquitin-protein ligase G1
Synonym symbol(s)	UBCH7, E217K, UBC7, UBE2G
EC.number	6.3.2.19

DNA

TYPE	functioning gene
STRUCTURE	97.46 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003342 6 - 4208 - 170 - 1999 10558980 V2 - - 3931 - 49 - 1999 10558980

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Endocrine parathyroid       highly Hearing/Equilibrium ear       highly Lymphoid/Immune lymph node       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a conserved UBC domain of 150 AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation

HOMOLOGY

interspecies

homolog to C.elegans UBC7

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	catalyzing the covalent attachment of ubiquitin to other proteins
	may be involved in degradation of muscle-specific proteins
	modulating the transcriptional activity of progesterone receptor (PR) and glucocorticoid, androgen, and retinoic acid receptors in a hormone-dependent manner
	playing a possible role in steroid receptor transactivation
	participating in ERAD
	UBE2G1 and UBE2G2 cooperate with IL17RB to polyubiquitylate and degrade CDT1 postradiation, an activity that is critical for preventing origin licensing in DNA-damaged cells

CELLULAR PROCESS	cell cycle
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a complex with UBE1, UBE2E2, UBE2D1, UBE3, CBL ubquitination complex

INTERACTION

DNA

RNA

small molecule

protein

interacts with steroid receptor coactivator 1, SRC-1 (coactivation function is dependent on SRC-1)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS