SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,nucleus,nucleoplasm
|
| intracellular,nucleus,chromatin/chromosome,heterochromosome
|
| intracellular,nucleus,nucleolus
|
text
| only associated with heterochromatin in G1 phase before it is degraded |
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during anaphase, ORC1 staining is localized mainly in the pericentriolar regions |
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ORC1, ORC3, and ORC5 all localize between the chromosomes at anaphase II, but could not be detected in zygotic G1 |
basic FUNCTION
| regulator of the initiation of DNA replication and transcription |
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preventing cyclin E-dependent reduplication of both centrioles and centrosomes in a single cell division cycle |
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regulating the status of the ORC complex in nuclei by tethering ORCs 2-5 to nuclear structures |
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involvement of ORC1, ORC2, ORC3 in the maintenance of constitutive heterochromatin |
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together with CBX proteins may be involved in organizing higher-order chromatin structure and centromere function |
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regulates centrosome duplication |
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required for DNA replication origin licensing |
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conserved role of ORC1 in modulating DNA structure to facilitate origin selection and helicase loading in eukaryotes |