basic FUNCTION
| ligand for the members of the frizzled members of receptors,modulating cell fate and cell behavior during vertebrate development |
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not required for cardiac differentiation, but functioning in regulation of cardiac morphogenesis |
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may be playing an important role in carcinogenesis through activation of the WNT signaling pathway |
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may be a key regulator of cardiac muscle cell proliferation and differentiation during heart development |
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has an essential role in the oriented elongation of the myocytes |
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required to control myocyte orientation and the action of the neural tube on the polarized elongation of myocytes is mediated, at least in part, by WNT11 |
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involved in coordination of key signaling pathways |
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promotes osteoblast maturation and mineralization, through RSPO2 |
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regulates the integration of intracellular and extracellular Ca2+, while also tuning dynamic relationships between subcellular Ca2+ domains, and refinement of electrical coupling by Wnt signals may be an important factor not only in cardiogenesis, but also in the establishment and maintenance of other epithelia in development |
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promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals |
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WNT5A and WNT11 are essential regulators of the response of second heart field progenitors to WNT/CTNNB1 signaling and they act by restraining WNT/CTNNB1 signaling during cardiac development |
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plays a crucial role in regulating MSC chondrogenic differentiation |
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WNT5A and WNT11 regulate epithelial-mesenchymal transition (EMT) by inducing p38 (MAPK14) phosphorylation |
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plays an important role in human mesenchymal stem cells (hMSCs) for enhancing the osteogenesis in an infectious environment |