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FLASH GENE
Symbol ABCB9 contributors: mct/npt - updated : 01-02-2008
HGNC name ATP-binding cassette, sub-family B (MDR/TAP), member 9
HGNC id 50
Location 12q23.31      Physical location : 123.413.539 - 123.459.752
Synonym name
  • multidrug resistance 4
  • TAP-like
  • ABC transporter 9 protein
  • Synonym symbol(s) MDR4, TAPL, KIAA1520, EST122234
    DNA
    TYPE functioning gene
    STRUCTURE 37.52 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure 60bp upstream sequence containing two GC-boxes from the transcriptional start site confers basal promoter activity
    MAPPING cloned Y linked N status provisional
    Map cen - D12S366 - RPLP0 - D12S86 - D12S349 - D12S321 - ACADS ACADS - RSN - ABCB9 - D12S342 - D12S340 - qter
    Authors Gene Map (98), LDB (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3546 - 766 testis Allikmets, Wolters, Ohashi-Kobayashi (2006)
    deleted of last pair of TM segments
    11 splicing 3417 - 723 several tissues Allikmets, Ohashi-Kobayashi (2006)
    - splicing 2588 - 683 - Kobayashi
  • also called TAPL12B
  • shorter carboxyl terminal amino acid sequences than 12A
  • 12 splicing 3814 - 766 - Kobayashi, Ohashi-Kobayashi (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
     spinal cord    
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal four transmembrane helices would be separately located from the core domain helices and may well interact with cellular components required for its lysosomal targeting (Kamakura 2008)
  • one ATP binding
  • one transmembrane (1TM) domain with ten potential transmembrane helices followed by a conserved ABC region
  • a nucleotide binding domain with WALKER motif
  • a ABC transporter domain
  • a peptidase C39 domain
  • HOMOLOGY
    interspecies homolog to rattus abcb9
    homolog to murine Abcb9
    homolog to murine Tapl
    intraspecies homolog to ABCB2,ABCB3
    Homologene
    FAMILY
  • ATP binding cassette superfamily
  • subfamily B (MDR/TAP)
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text detected in the lysosomal compartment co-localizing with the lysosome-associated membrane protein LAMP2, and LAMP1
    basic FUNCTION
  • half-ABC transporter, traffic ATPase, may play a role in lysosomes
  • involved in multidrug resistance as well as antigen presentation
  • may be the key link missing in the chaperone-mediated autophagy and a novel route discharging cytosolic antigens in lysosomal compartments induced in professional antigen-presenting cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by during differentiation of monocytes to dendritic cells and to macrophages
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS