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FLASH GENE

Symbol

RHCE

contributors: mct - updated : 09-11-2011

HGNC name	Rhesus blood group, CcEe antigens
HGNC id	10008

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020485 10 - 1618 - 417 - Tax variant 1 RhVIII NM_138618 9 - 1484 - 354 - - lacking an internal exon truncated also called Rh4 NM_138616 7 - 1163 - 266 - Tax lacking three internal exon,same ORF variant 1 RhVIII NM_138617 8 - 1223 - 267 - - also called RhVI lacking an internal exon truncated

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte

cell lineage	erytroid/megakaryocyte lineage
	transcribed in bone marrow-derived mesenchymal stem cells (MSCs)
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP , Other

HOMOLOGY

Homologene

FAMILY

CATEGORY

antigen , transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	encoding the C/c,E/e antigens
	RHCE and RHD, may not function directly in ammonia transport and may be evolving a new function in the red blood cell membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	ammonium transport

PATHWAY

metabolism

signaling

a component	component of a complex with SMP1, RHD and RHAG
	component of a complex with RHD, Rh-associated glycoproteins (RhAG and accessory chains (SMP1 and others) associated by noncovalent bonds

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RH , RHNA , RHECT

related resource

Blood Group Antigen Mutation Database

Susceptibility

to phenotype JAL+

Variant & Polymorphism other	phenotype JAL+ results from a nucleotide 340C>T (Arg114Trp) on either a Ce or ce background

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS