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FLASH GENE

Symbol

RHCE

contributors: mct - updated : 09-11-2011

HGNC name	Rhesus blood group, CcEe antigens
HGNC id	10008

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene, opposite orientation, tail to tail
text	arranged tail to tail with RHD
	SMP1 overlapping 3 prime end and 3 prime UTR of RHCE
STRUCTURE	58.64 kb     10 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence   ALU   other
text structure	mutational hot spots and low K values (number of substitutions for nucleotide site)
	various STR (short tandem repeats 25.7p100 of Alu concentrated in several regions)

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - RHCE - SMP1 - RHD - cen
Authors	Suto (00)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020485 10 - 1618 - 417 - Tax variant 1 RhVIII NM_138618 9 - 1484 - 354 - - lacking an internal exon truncated also called Rh4 NM_138616 7 - 1163 - 266 - Tax lacking three internal exon,same ORF variant 1 RhVIII NM_138617 8 - 1223 - 267 - - also called RhVI lacking an internal exon truncated

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte

cell lineage	erytroid/megakaryocyte lineage
	transcribed in bone marrow-derived mesenchymal stem cells (MSCs)
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP , Other

HOMOLOGY

Homologene

FAMILY

CATEGORY

antigen , transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	encoding the C/c,E/e antigens
	RHCE and RHD, may not function directly in ammonia transport and may be evolving a new function in the red blood cell membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	ammonium transport

PATHWAY

metabolism

signaling

a component	component of a complex with SMP1, RHD and RHAG
	component of a complex with RHD, Rh-associated glycoproteins (RhAG and accessory chains (SMP1 and others) associated by noncovalent bonds

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RH , RHNA , RHECT

related resource

Blood Group Antigen Mutation Database

Susceptibility

to phenotype JAL+

Variant & Polymorphism other	phenotype JAL+ results from a nucleotide 340C>T (Arg114Trp) on either a Ce or ce background

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS