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FLASH GENE

Symbol

RHD

contributors: mct - updated : 15-11-2011

HGNC name	Rhesus blood group, D antigen
HGNC id	10009

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016124 10 - 2833 45 417 - 1999 9920819 NM_001127691 7 splicing 2545 - 321 exclusively in an erythroleukemia cell line 1999 9920819 lacking two internal exons frameshift variant RHDVA - - - - - - 1999 9920819 hybrid RHCE-RHD

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       stomach         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

twelve transmembrane segments (12TM)

HOMOLOGY

Homologene

FAMILY

CATEGORY

antigen , transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in ammonium transport
	RHCE and RHD, may not function directly in ammonia transport and may be evolving a new function in the red blood cell membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of a complex with RHCE
	fatty acylated integral red cell membrane protein component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

cell surface expression posttranscriptionally regulated by RHAG

ASSOCIATED DISORDERS

corresponding disease(s)

RH , RHECT

Susceptibility

Variant & Polymorphism other	totally or partially absent in the Caucasian RH-negative phenotype

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS