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FLASH GENE
Symbol PLCB2 contributors: mct - updated : 11-07-2013
HGNC name phospholipase C, beta 2
HGNC id 9055
Location 15q15.1      Physical location : 40.580.098 - 40.600.174
Synonym name
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
  • Synonym symbol(s) FLJ38135
    EC.number 3.1.4.3, 3.1.4.11
    DNA
    TYPE functioning gene
    STRUCTURE 20.08 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    THBS1 15q15 thrombospondin 1 FLJ35989 15q14 hypothetical protein FLJ35989 GPR 15q14 putative G protein coupled receptor LOC388113 15 hypothetical gene supported by BC035481 MGC10997 15q13-q14 pseudogene MGC10997 SRP14 15q15.1-q21.1 signal recognition particle 14kDa (homologous Alu RNA binding protein) BMF 15q14 Bcl2 modifying factor BUB1B 15q15 BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) PAK6 15q14 p21(CDKN1A)-activated kinase 6 LOC390577 15 similar to KIAA1728 protein PLCB2 15q15 phospholipase C, beta 2 LOC390578 15 similar to BLOCK 23 LOC388114 15 LOC388114 LOC388115 15 similar to RIKEN cDNA 2600011L02 LOC146071 15q14 similar to RIKEN cDNA 1810007E14; EST AA238765 DISP2 15q14 dispatched homolog 2 (Drosophila) FLJ14502 15q14 TRAF4 associated factor 1 IVD 15q14-q15 isovaleryl Coenzyme A dehydrogenase KIAA0945 D4ST-1 15q14 isovaleryl Coenzyme A dehydrogenase MGC20481 15q14 hypothetical protein MGC20481 C18B11 15q13.3 C18B11 homolog (44.9kD) AF15Q14 15q14 AF15q14 protein RAD51 15q15.1 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) FLJ10579 15q14 hypothetical protein FLJ10579 GCHFR 15q15 GTP cyclohydrolase I feedback regulatory protein FLJ10634 15q14 hypothetical protein FLJ10634 ZFYVE19 15q14 zinc finger, FYVE domain containing 19 PPP1R14D 15q13.3 protein phosphatase 1, regulatory (inhibitor) subunit 14D SPINT1 15q15 serine protease inhibitor, Kunitz type 1 ARHV 15q13.3 ras homolog gene family, member V VPS18 15q14-q15 vacuolar protein sorting protein 18 DLL4 15q14 delta-like 4 (Drosophila) MGC4504 15q14 hypothetical protein MGC4504 KIAA1259 15q14 hypothetical protein MGC4504 HCP37 15q15.1 cytochrome c, somatic pseudogene LOC388116 15 similar to RIKEN cDNA 6720467C03 MGC33637 15q14 hypothetical protein MGC33637
    RNA
    TRANSCRIPTS type messenger
    text presence of transcripts of two forms of PLCB2 generated by alternative splicing (PMID: 17497434)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 4694 - 1185 . expressed in platelets at the protein level . higher cytoplasmic to nuclear ratio for PLCB2b compared to PLCB2a, suggesting that a great proportion of the total PLCB2a was in the nucleus relative to PLB2b 2007 17497434
  • PLCB2a
  • - splicing - - 1170 . expressed in platelets at the protein level . higher cytoplasmic to nuclear ratio for PLCB2b compared to PLCB2a, suggesting that a great proportion of the total PLCB2a was in the nucleus relative to PLB2b 2007 17497434
  • lacking 15 AAs (corresponding to 864-878)
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
     tonsils    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    Blood/Hematopoieticplatelet Homo sapiens
    cell lineage predominantly, in hematopoietic cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text
  • WDR26 is required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes
  • basic FUNCTION
  • phospholipase C, beta 2, phosphatidylinositol specific
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli, critical to many chemoattractant elicited responses
  • in differentiating cells, the association of PLCB2 with actin, mediated by the PH domain, seems crucial for catalytic activity
  • plays a pivotal role in G-protein dependent signal transduction in platelets
  • PLCB2, PLCB3 play a critical role in T lymphocyte chemotaxis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds strongly to PLCdelta1(PLCD1) and inhibits its catalytic activity
  • activity of PLCD1 is controlled by the amount of bound PLCB2 that changes with displacement of the enzyme by heterotrimeric or small G proteins
  • WDR36 associated with PLCB2 and increased the interaction between GNAQ and PLCB2, but prevented sequestration of activated GNAQ by GRK2
  • interaction between SLC9A3R1 and CXCR2 or PLCB2 is PDZ motif-dependent
  • WDR26 is required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes, and the translocation of PLCB2 was sufficient to cause partial activation of PLCB2
  • cell & other
    REGULATION
    activated by RAC1, that can activate PLCB2 to increase intracellular Ca(2+) levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    suppression of PLCB2 plays an important role in switching M1 macrophages into an M2-like state
    constitutional       loss of function
    loss of PLCB2 and PLCB3 significantly impaired T cell migration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    target for novel therapeutic breast cancer strategies
    ANIMAL & CELL MODELS