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FLASH GENE
Symbol CDC34 contributors: mct/npt - updated : 24-11-2009
HGNC name cell division cycle 34 homolog (S. cerevisiae)
HGNC id 1734
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • E2 core providing specificity to CDKN1B, and the AAs 184-196 are required for possessive ubiquitination by CDC34 (Ryu 2008)
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae CDC34
    Homologene
    FAMILY
  • ubiquitin conjugating enzyme family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in late G1 to S transition regulator of the cell cycle
  • ubiquitin conjugating enzyme E2, required for the poly ubiquitination of NFKBI
  • E2-conjugating enzyme required for catalyzing the polyubiquitination reaction mediated by the Skp1.CUL1.F-box (SCF) protein E3 ubiquitin (Ub) ligase (Gazdoiu 2005)
  • controls cellular proliferation through regulation of CDKN1B protein levels (Butz 2005)
  • catalyzes polyubiquitination of a substrate recruited by the Skp1-Cullin 1-F-box protein-ROC1 E3 Ub ligase (Gazdoiu 2007)
  • employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains (Gazdoiu 2007)
  • plays an essential role in promoting the G1-S-phase transition of the eukaryotic cell cycle (Sadowski 2007)
    • CELLULAR PROCESS cell cycle, checkpoint
    protein
    PHYSIOLOGICAL PROCESS
    text ubiquitin dependent proteolysis in proteosomes
    PATHWAY
    metabolism
    signaling
    a component
  • component of the complex SCF (SKP1/CDC53-CUL1) /F-box rotein (SKP2), involved in the ubiquitin-proteasome degradation system
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other required for polyubiquination of NFKBIA
    recruted by the complex SCF (SKP1/CDC53-CUL1) /F-box protein (SKP2)
    regulated by phosphorylation (CDC34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression) (Sadowski 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS