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FLASH GENE
Symbol CDC34 contributors: mct/npt - updated : 24-11-2009
HGNC name cell division cycle 34 homolog (S. cerevisiae)
HGNC id 1734
Location 19p13.3      Physical location : 531.732 - 542.086
Synonym name
  • ubiquitin-conjugating enzyme E2,32 Kda complementing
  • ubiquitin carrier protein
  • cell division cycle 34
  • Synonym symbol(s) E2-CDC34, UBE2R1, UBC3
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 10.36 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1462 - 236 - Plon (1993)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   highly
     thyroid   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines many cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • E2 core providing specificity to CDKN1B, and the AAs 184-196 are required for possessive ubiquitination by CDC34 (Ryu 2008)
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae CDC34
    Homologene
    FAMILY
  • ubiquitin conjugating enzyme family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in late G1 to S transition regulator of the cell cycle
  • ubiquitin conjugating enzyme E2, required for the poly ubiquitination of NFKBI
  • E2-conjugating enzyme required for catalyzing the polyubiquitination reaction mediated by the Skp1.CUL1.F-box (SCF) protein E3 ubiquitin (Ub) ligase (Gazdoiu 2005)
  • controls cellular proliferation through regulation of CDKN1B protein levels (Butz 2005)
  • catalyzes polyubiquitination of a substrate recruited by the Skp1-Cullin 1-F-box protein-ROC1 E3 Ub ligase (Gazdoiu 2007)
  • employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains (Gazdoiu 2007)
  • plays an essential role in promoting the G1-S-phase transition of the eukaryotic cell cycle (Sadowski 2007)
  • CELLULAR PROCESS cell cycle, checkpoint
    protein
    PHYSIOLOGICAL PROCESS
    text ubiquitin dependent proteolysis in proteosomes
    PATHWAY
    metabolism
    signaling
    a component
  • component of the complex SCF (SKP1/CDC53-CUL1) /F-box rotein (SKP2), involved in the ubiquitin-proteasome degradation system
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other required for polyubiquination of NFKBIA
    recruted by the complex SCF (SKP1/CDC53-CUL1) /F-box protein (SKP2)
    regulated by phosphorylation (CDC34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression) (Sadowski 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS