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FLASH GENE
Symbol CASP7 contributors: mct - updated : 21-01-2011
HGNC name caspase 7, apoptosis-related cysteine peptidase
HGNC id 1508
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
  • a conserved QACXG pentapeptide active site motif
    • mono polymer heteromer , dimer
    isoforms Precursor precursor producing two subunits, large and small that dimerize
    HOMOLOGY
    interspecies homolog to rattus Casp7 (85,15 pc)
    homolog to murine Casp7 (82,18 pc)
    Homologene
    FAMILY
  • peptidase C14 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus,nucleoplasm
    text stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli
    basic FUNCTION
  • cysteine containing aspartate-specific protease
  • involved in the execution phase of apoptosis
  • CASP3 was found to be generally more promiscuous than CASP7 and appears to be the major executioner caspase during the demolition phase of apoptosis
  • executioner caspase that plays a key role in apoptosis, cancer, and a number of neurodegenerative diseases
  • calpain-activated form of caspase-7 has unique enzymatic activity, localization, and binding affinity when compared with the caspase-activated form
  • considered to be redundant with CASP3 because these related cysteine proteases share an optimal peptide recognition sequence and have several endogenous protein substrates in common
  • CASP3 and CASP7 exhibit differences in protease activity, specific homodimer-forming activity, and three-dimensional structural features, all of which are closely interrelated
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaving and activating sterol regulatory element binding proteins
  • cleaving poly (adp-ribose) polymerase (PARP)
  • calpain during B cell clonal deletion by apoptosis
  • binding to and ubiquitinated by BIRC2
  • CAPN1-activated form of CASP7 has unique enzymatic activity, localization, and binding affinity when compared with the caspase-activated form
  • presynaptic protein ATCAY is a substrate of CASP3 and CASP7
  • after activation by CASP9, CASP3 inhibits ROS production and is required for efficient execution of apoptosis, while effector CASP7 is required for apoptotic cell detachment
    • cell & other
    REGULATION
    induced by PHB on the CASP7 promoter mediated through p53 binding sites
    inhibited by BIRC2, BIRC3, BIRC4 (XIAP)
    Other regulated by its terminal peptide
    positively controlled by SREBF1 and SREBF2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in several solid cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target interfering with CASP7 activation may hold therapeutic value for the treatment of cancer
    SystemTypeDisorderPubmed
    cancer  
    ANIMAL & CELL MODELS