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FLASH GENE
Symbol DPF1 contributors: mct/npt - updated : 09-05-2018
HGNC name D4, zinc and double PHD fingers family 1
HGNC id 20225
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • highly-conserved N-terminal 84-AA region (designated "CT1") can function as an efficient dominant-negative mutant of the entire d4-family proteins
  • zinc finger-like structural motif/two PHD-type zinc fingers
    • HOMOLOGY
    interspecies ortholog to murine Neud4
    homolog to rattus Neud4
    Homologene
    FAMILY
  • requiem/DPF family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in induction of apoptosis
  • having an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor
  • DPF1, DPF2, DPF3 function as adaptor proteins linking NFKB1 with the SWI/SNF complex
    • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    DPF1 is a potential therapeutic targets for glioblastoma
    ANIMAL & CELL MODELS