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FLASH GENE

Symbol

PIGB

contributors: mct - updated : 10-09-2019

HGNC name	phosphatidylinositol glycan anchor biosynthesis, class B
HGNC id	8959

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PIGBD phosphatidylinositol glycan, class B deficiency
Location	15q21.3      Physical location : 55.611.132 - 55.647.845
Synonym name	phosphatidylinositol glycan, class B
Synonym symbol(s)	MGC21236, GPI-MT-III, PIG-B
EC.number	2.4.1.198

DNA

TYPE	functioning gene
STRUCTURE	36.71 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004855 12 - 1910 NP_004846 - 554 - 1996 8861954

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune lymph node       highly Urinary bladder       highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte

cell lineage	stem cell hematopoietic
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a glycosyltransferase motif

HOMOLOGY

Homologene

FAMILY

dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	glycosyl-phosphatidylinositol (GPI) anchor synthesis,class B, involved in transferring the third mannose of the GPI anchor for cell surface proteins
	transfers the third mannose to the GPI precursor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PIGBD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS