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FLASH GENE
Symbol RTN2 contributors: mct - updated : 14-04-2008
HGNC name reticulon 2
HGNC id 10468
Location 19q13.32      Physical location : 45.988.550 - 46.000.313
Synonym name
  • reticulon 2, neuroendocrine specific protein-like sequence 1
  • NSP-like protein 1
  • Neuroendocrine-specific protein-like 1
    • Synonym symbol(s) NSP2, NSPL1
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 2317 59.3 545 - Roerbroek, Ballif (2004)
    10 splicing 2100 51.4 472 - Roerbroek, Ballif (2004)
  • lacking exon 5
  • member of the reticulon protein family that mainly localizes in the ER and ER exit sites interacts with SLC1A1 and ARL6IP5
  • functions as a positive regulator in the delivery of SLC1A1 from the ER to the cell surface
    • - initiation site 1300 22.3 205 high expression in muscle Roerbroek, Ballif (2004)
    starting with AA 341
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Respiratoryrespiratory tractlarynx  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal luminal, negatively charged domain
  • two hydrophobic transmembrane segments (TH2)
  • a conserved C terminal region
    • HOMOLOGY
    Homologene
    FAMILY reticulon family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text anchored to membranes of the endoplasmic reticulum through its carboxy-terminal regions
    basic FUNCTION
  • involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS