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FLASH GENE

Symbol

LTB4R

contributors: mct/npt - updated : 19-03-2010

HGNC name	leukotriene B4 receptor
HGNC id	6713

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q12      Physical location : 24.780.704 - 24.787.241
Synonym name	purinoceptor P2Y type 7, group 1
	chemokine receptor-like 1
	G protein-coupled receptor 16
	chemoattractant receptor-like 1
Synonym symbol(s)	CMKRL1, P2RY7, BLT1, BLTR, GPR16, LTB4R1, LTBR1, P2Y7

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene
STRUCTURE	6.35 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

promoter region embedding BLTR2

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	with two alternatively spliced isoforms, 7.5 and 5kb (Owman)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001143919 2 - 2723 NP_001137391 - 352 - Maier (1997) NM_181657 2 - 4331 NP_858043 - 352 - Maier (1997)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Lymphoid/Immune spleen       highly Nervous brain         Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage
cell lines	osteoblastic and brain cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in the regulation of the inflammatory system
	predominantly responding to ATP, involved in the regulation of cardiac muscle contraction
	major neutrophil chemotactic factor released from the intraluminal thrombus of abdominal aortic aneurysms (Houard 2009)
	G-protein-coupled receptors for leukotriene B4 functioning in host defense, inflammation, and immunity (Kuniyeda 2007)
	in granulocytes transducing intracellular signals through the Gi- and G16-classes of G proteins, which inhibit cAMP production and raise the intracellular calcium concentration (Hikiji 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand LTB4 (LTB4 is produced in osteoclasts and activates LTB4R in an autocrine/paracrine manner) (Hikiji 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	inhibition of LTB4R functions may represent a strategy for preventing bone resorption diseases (potential therapeutic target for bone resorption diseases) (Hikiji 2009)

ANIMAL & CELL MODELS

osteoclasts from Blt1-deficient mice showed reduced calcium resorption activities compared with wild-type osteoclasts (Hikiji 2009)