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FLASH GENE

Symbol

POU2F2

contributors: mct - updated : 19-11-2016

HGNC name	POU domain, class 2, transcription factor 2
HGNC id	9213

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly   thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DNA binding protein, with POU specific and POU homeo (helix-turn-helix) domains
	potential leucine zipper domain

HOMOLOGY

interspecies	homolog to murine Pou2f2
	homolog to C.elegans c30a5.7b

Homologene

FAMILY

class II POU homeodomain family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	involved in the control of the forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female puberty
	playing a role in regulating transcription in a number of tissues in addition to activating immunoglobulin gene expression
	playing an essential role during the terminal phase of B cell differentiation
	with POU2F2, are B-cell associated transcription factors expressed in a subset of patients with acute myeloid leukemia (AML)
	POU2AF1 together with POU2F1/POU2F2, binds to octamer sites in promoters and enhancers to activate transcription of immunoglobulin (Ig) genes
	POU2F1 and GATA3/POU2F2 direct Th2 cytokine gene expression in a cooperative manner

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to the octamer motif ATGCAAAT

RNA

small molecule

protein	ZNF593
	repressing the involucrin promoter activity in epithelial cells and in the presence of the silencer element(when overexpressed)
	POU2AF1 is a B lymphocyte-specific transcription factor which coactivates POU2F1 and POU2F2 on B cell specific promoters
	PDCD1LG2 expression is regulated by two different promoters that function in a lineage-specific manner, with the B-1-specific promoter being constitutively active as a result of POU2F1 and POU2F2 binding
	a putative defect in POU2F1 and/or POU2F2, by affecting HMGA1 expression, may cause INSR dysfunction, leading to defects of the INSR signaling pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   expressed in systemic anaplastic large cell lymphomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS