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FLASH GENE

Symbol

NRAS

contributors: mct - updated : 06-05-2016

HGNC name	neuroblastoma RAS viral (v-ras) oncogene homolog
HGNC id	7989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NS6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in multiple myeloma, in primary plasma cell leukemia at an early stage, and in thyroid cancer with poor prognosis tumoral germinal mutation     gain of function in autoimmune lymphoproliferative syndrome tumoral somatic mutation       in high hyperdiploid childhood acute lymphoblastic leukemia tumoral somatic mutation       in hepatocellular carcinoma tumoral somatic mutation       in primary melanocytic tumours of the CNS, GNA11 and NRAS mutations represent a mechanism of MAPK pathway activation alternative to the common GNAQ mutations( :

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

effect of Nras loss on tumor development in Rb1 heterozygous mice, the loss of the protooncogene Nras in certain cellular contexts can promote malignant tumor progression (Takahashi 2006)