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FLASH GENE
Symbol NP contributors: SGE/npt - updated : 28-08-2009
HGNC name nucleoside phosphorylase
HGNC id 7892
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver    
 pharynx   highly
Endocrineparathyroid   highly
Lymphoid/Immunethymus    
Reproductivefemale systemuterus   
Urinarykidney    
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer homomer , trimer
HOMOLOGY
interspecies homolog to rattus Np (85.1pc)
Homologene
FAMILY
  • PNP/MTAP phosphorylase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a key role in the purine salvage pathway, catalyzing the phosphorolysis of purine nucleosides
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    purine catabolism
    a component
  • SUPV3L1 dimer and NP trimer form a 330kDa heteropentamer capable of efficiently degrading dsRNA substrates in the presence of ATP, complex that may be the RNA-degrading complex in the mitochondria (Wang 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHD
    related resource NPbase: Mutation registry for PNP deficiency
    Susceptibility
    Variant & Polymorphism SNP G51S polymorphism is associated with a faster rate of cognitive decline in A.D patients (Tumini 2007)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS