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FLASH GENE

Symbol

NP

contributors: SGE/npt - updated : 28-08-2009

HGNC name	nucleoside phosphorylase
HGNC id	7892

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	7.71 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000270 6 - 1514 NP_000261 - 289 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   liver           pharynx       highly Endocrine parathyroid       highly Lymphoid/Immune thymus         Reproductive female system uterus       Urinary kidney

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

mono polymer

homomer , trimer

HOMOLOGY

interspecies

homolog to rattus Np (85.1pc)

Homologene

FAMILY

PNP/MTAP phosphorylase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

playing a key role in the purine salvage pathway, catalyzing the phosphorolysis of purine nucleosides

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

purine catabolism

a component

SUPV3L1 dimer and NP trimer form a 330kDa heteropentamer capable of efficiently degrading dsRNA substrates in the presence of ATP, complex that may be the RNA-degrading complex in the mitochondria (Wang 2009)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NPHD

related resource

NPbase: Mutation registry for PNP deficiency

Susceptibility

Variant & Polymorphism SNP

G51S polymorphism is associated with a faster rate of cognitive decline in A.D patients (Tumini 2007)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS