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FLASH GENE
Symbol VAMP2 contributors: mct/npt/pgu - updated : 30-06-2015
HGNC name vesicle-associated membrane protein 2 (synaptobrevin 2)
HGNC id 12643
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal half of the SNARE motif of VAMP2 serves as a sorting determinant for recognition by the related ANTH domain-containing endocytic adaptor
  • C terminus with a potential role in fusion pore formation
    • secondary structure one alpha helix contributing to the four helix bundle of synaptic SNARE complex
    HOMOLOGY
    Homologene
    FAMILY
  • synaptobrevin family
    • CATEGORY regulatory , structural protein , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • fusion of synaptic vesicles to target membranes
  • VAMP1 and VAMP2, both co-sediment and co-localize with NPPA
  • colocalized with CPLX2 along the apical plasma membrane following cholecystokinin-8 stimulation
  • SEMA3A receptor and VAMP2 colocalize in endosomal membranes
    • basic FUNCTION
  • soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein
  • calcium dependent role in the docking and fusion of synaptic vesicles with the presynaptic membrane
  • role for both myosin Va and VAMP2 in oligodendrocyte function as it relates to myelination
  • playing a central role in neural exocytosis
  • regulate GLUT4 trafficking in slow-twitch myofibers in soleus muscle and neurotransmitter release in nerve endings
  • plays roles in quiescent satellite cells and is involved in muscle regeneration
  • VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival
  • with VAMP1, and syntaxin-4 regulate NPPA release from cardiac myocyte
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • essential for T3 to increase insulin-stimulated translocation of SLC2A4 and subsequent uptake of glucose in adipocytes
  • most abundant synaptic vesicle protein, required for fast calcium-triggered synaptic vesicle fusion
  • SEMA3A-mediated signaling and axonal repulsion require VAMP2-dependent vesicular traffic
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of a synaptic core complex with syntaxin and synaptosome associated proteins (SNAP25)
  • critical component of the synaptic vesicle--fusion machinery
  • three SNAREs, STX4, VAMP1 and VAMP2, form a SNARE complex inside cardiac myocytes
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • binding to t-SNARES, syntaxin (STXs) and SNAP25 after the fusion of synaptic vesicles to plasma membrane
  • interacting with PRKD3 (may regulate VAMP2 vesicle trafficking by facilitating its recruitment to the target membrane)
  • VAMP2 and RAB3A are SNARE proteins that interact with RABAC1
  • VAMP2 is interaction partner of WDFY2 (with VAMP2, WDFY2 may be involved in vesicle cycling in various secretory pathway)
  • association of VAMP2 with synaptophysin I in the specification of the pathway of synaptic vesicle biogenesis
  • interacting with PICALM (facilitates the endocytosis of the synaptic vesicle protein VAMP2 from the plasma membrane)
  • interacting with SLC2A4 (VAMP2 required for sorting to the specialized insulin-responsive compartment after plasma membrane endocytosis)
  • interaction of STXBP4 with STX4 prevents interaction of VAMP2 located in SLC2A4 vesicle with STX4 in basal state
  • interacts with SNAP-25 and syntaxin-1 to form a stable SNARE complex
  • SEPT8 suppresses the interaction between VAMP2 and synaptophysin through binding to VAMP2
  • modulates KCNB1 inactivation by interfering with the interaction between the docking loop and C1a, a mechanism for gating regulation that may pertain also to other Kv channels
  • interacting with STXBP5 (tail domain of STXBP5 controlled membrane fusion though STXBP5 displacement by VAMP2)
  • CPLX2 interact with vesicle-associated membrane protein (VAMP2), syntaxins 3 and 4, but not with VAMP8 or syntaxin 2
  • PICALM controls the level of the synaptic vesicle protein VAMP2 at the plasma membrane by regulating VAMP2 endocytosis
  • associated with Neuropilin 1 (NRP1) and PLXNA1, two essential components of the SEMA3A receptor, via its juxtatransmembrane domain
    • cell & other
  • targeted to renin-containing granules and mediates the stimulatory effect of cAMP on renin exocytosis
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS