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FLASH GENE
Symbol TAC3 contributors: mct/npt - updated : 06-06-2015
HGNC name tachykinin 3
HGNC id 11521
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • tachykinin family
    • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • potent vasodilator and secretagogue, and contracting (directly or indirectly) many smooth muscles
  • paracrine modulator of tone in the fetal placental circulation (Brownbill 2004)
  • critical central regulator of gonadal function (Topaloglu 2009)
  • TAC3/TACR3 have been implicated in the neuroendocrine control of GNRH1 release
  • TAC3 and its preferred tachykinin receptor 3 (TACR3) are prominently detected in the central nervous system, playing significant roles in physiological development and specifically in the human reproductive system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHGT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in women with pre-eclampsia during the third trimester of pregnancy (increased placental expression of TAC3 is part of the mechanism leading to the increased circulating levels of TAC3 in pre-eclampsia)(Page 2006)
    constitutional     --over  
    of TAC3 and UTS2 in the plasma of pre-eclamptic women
    Susceptibility
    Variant & Polymorphism
    Candidate gene TAC3/TACR3 system may provide a new avenue for the pharmacological manipulation of human fertility and the treatment of sex steroid–related diseases, such as cancers of the breast and prostate (Topaloglu 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS