Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TAC3 contributors: mct/npt - updated : 06-06-2015
HGNC name tachykinin 3
HGNC id 11521
Corresponding disease
HHGT hypogonadotropic hypogonadism, familial
Location 12q13.3      Physical location : 57.403.781 - 57.410.344
Synonym name
  • tachykinin 3 (neuromedin K, neurokinin beta)
  • gamma tachykinin 3
  • neurokinin B-like protein
  • preprotachykinin B
  • Synonym symbol(s) NKA, NKNB , ZNEUROK1, TKNK, NKB, PRO1155
    DNA
    TYPE functioning gene
    STRUCTURE 6.54 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 832 13.31 121 - Topaloglu (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus predominantly Homo sapiens
    Reproductivefemale systemovary    Homo sapiens
     female systemoviduct    Homo sapiens
     female systemuterus    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, syncytiotrophoblast
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • tachykinin family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • potent vasodilator and secretagogue, and contracting (directly or indirectly) many smooth muscles
  • paracrine modulator of tone in the fetal placental circulation (Brownbill 2004)
  • critical central regulator of gonadal function (Topaloglu 2009)
  • TAC3/TACR3 have been implicated in the neuroendocrine control of GNRH1 release
  • TAC3 and its preferred tachykinin receptor 3 (TACR3) are prominently detected in the central nervous system, playing significant roles in physiological development and specifically in the human reproductive system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHGT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in women with pre-eclampsia during the third trimester of pregnancy (increased placental expression of TAC3 is part of the mechanism leading to the increased circulating levels of TAC3 in pre-eclampsia)(Page 2006)
    constitutional     --over  
    of TAC3 and UTS2 in the plasma of pre-eclamptic women
    Susceptibility
    Variant & Polymorphism
    Candidate gene TAC3/TACR3 system may provide a new avenue for the pharmacological manipulation of human fertility and the treatment of sex steroid–related diseases, such as cancers of the breast and prostate (Topaloglu 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS