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FLASH GENE
Symbol NID1 contributors: mct - updated : 24-03-2006
HGNC name nidogen 1
HGNC id 7821
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six EGF-like domains
  • four LDL-receptor class B repeats
  • one NIDO (nidogen-like) domain
  • one nidogen G2 beta-barrel domain
  • one thyroglobulin type-1 domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Nid1
    homolog to rattus Nid1
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basement membrane, extracellular matrix
    basic FUNCTION playing a role in cell-extracellular matrix interactions
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component constituent of cutaneous basement membrane zones (entactin)
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ion Ca2+
    • protein
  • binding collagens
  • forming a highly stable noncovalent complex with laminin
  • binding perlecan (IG3 domain), nidogen 2
  • interacting with FBLN1 and LGALS3BP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    lack of nidogen-1 and -2 results in a specific and time-limited failure in the ectodermal basement membrane of the limb bud, causing dysregulation of interdigital apoptosis and syndactyly