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FLASH GENE

Symbol

NGFR

contributors: mct/shn/ - updated : 11-10-2017

HGNC name	nerve growth factor receptor
HGNC id	7809

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   expressed in melanomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   unanticipated function of NGFR as a unique regulator of glucose metabolism and insulin sensitivity

ANIMAL & CELL MODELS

	mice with NGF receptor p75 mutation are viable and fertile display markedly decreased sensory innervation, loss of heat sensitivity associated with ulcers in the distal extremities
	light-induced photoreceptor apoptosis in p75NTR knockout mice is significantly reduced
	impairment of hippocampal long-term potentiation in p75NTR-deficient mouse
	mice depleted for p75NTR exacerbate liver pathology and inhibited hepatocyte proliferation in vivo