| basic FUNCTION
| GTPase activating protein, modulating cytoskeleton-mediated-processes |
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function as a negative regulator of Ras and required in endothelial cells but do not rule out a simultaneous requirement in the neural crest during cardiac development |
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regulator of RAS-induced signals in primary vascular smooth muscle cells |
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playing a critical role for normal histogenesis during embryologic development and wound healing |
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having a function in the modulation of excitability of sensory neurons |
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having an important role in the development of joints, as shown by fusion of the hip joints and other joint abnormalities and multiple essential roles in skeletal development and growth |
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plays a crucial role in modulating mesenchymal stem/progenitor cells differentiation into osteoblasts, and the defect in osteoblast differentiation may contribute at least in part to the osseous abnormalities seen in individuals with NF1 |
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in inhibitory neurons regulates ERK-dependent phosphorylation of synapsin I and consequently GABA release |
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having a critical role in hypothalamic–pituitary axis function in a Ras-independent fashion |
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may function in the mammalian central nervous system (CNS) by modulating either Ras- or cAMP-dependent pathways |
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required for normal glial and neuronal development involving separable Ras-dependent and cAMP-dependent mechanisms  |
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regulates activity-dependent GABA release in prefrontal cortex |
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important molecular regulator of interneuronal activity in the prefrontal cortex and striatum, brain regions critical for working memory performance |
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regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner |
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requirement of neurofibromin for muscle formation and maintenance |
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required for the control of MAPK signaling in various cell types, including cardiac and muscle cells |
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directly regulates osteoclastogenesis through MTOR signaling pathway |
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controls astrocyte growth in an AKT1-dependent, but TSC/RHEB-independent, fashion relevant to gliomagenesis |
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regulates CNS neurite length and growth cone areas in a cAMP/PKA/Rho/ROCK-dependent manner |
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regulatory role for NF1 during epicardial epithelial to mesenchymal transition (EMT) |
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by restraining RAS-ERK1/2 signaling, is a negative regulator of FGFR signaling in differentiating chondrocytes |
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is essential for normal muscle function and survival and are the first to suggest a direct link between NF1 and mitochondrial fatty acid metabolism |
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is the major RAS inactivator in dendritic spines |
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inactivates the oncoprotein RAS and plays important roles in nervous system development and learning |
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likely involved in the regulation of mechanical sensing, bone matrix composition and mechanical resistance of bone tissue |
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NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development |
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in prehypertrophic chondrocytes, downstream of FGFR1and FGFR3 and via an indirect mechanism, is required for normal extension and organization of proliferative columns |
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role for NF1 in the melanocyte lineage |
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differentially controls neural stem cell (NSC) proliferation and multilineage differentiation through the selective use of the PI3K/AKT1 and RAF/MEK pathways |
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during mitosis, is an integral part of the spindle, while its depletion leads to aberrant chromosome congression, possibly explaining the development of chromosomal instability in NF1 |
