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FLASH GENE

Symbol

NARS1

contributors: mct - updated : 16-09-2020

HGNC name	asparaginyl-tRNA synthetase
HGNC id	7643

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	21.18 kb     14 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

Map	see SERPINB2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004539 14 - 2762 NP_004530 - 548 - 1998 9421509

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases

HOMOLOGY

Homologene

FAMILY

class II family of tRNA synthetases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in autoimmune reactions
	is required to meet protein synthetic needs and to support radial glial cells (RGCs) proliferation in brain development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MNDDSA

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS