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FLASH GENE
Symbol VAMP1 contributors: mct - updated : 29-06-2011
HGNC name vesicle-associated membrane protein 1 (synaptobrevin 1)
HGNC id 12642
Corresponding disease
SPAX1 spastic ataxia 1
Location 12p13.31      Physical location : 6.571.405 - 6.579.843
Synonym symbol(s) DKFZp686H12131, SYB1, VAMP-1
DNA
TYPE functioning gene
STRUCTURE 8.44 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
CD9 12p13.31 CD9 antigen (p24) FLJ10665 12p13.32 hypothetical protein FLJ10665 TNFRSF1A 12p13.2 tumor necrosis factor receptor superfamily, member 1A SCNN1A 12p13.3 sodium channel, nonvoltage-gated 1 alpha LTBR 12p13.31 lymphotoxin beta receptor (TNFR superfamily, member 3) LOC390283 12 hypothetical gene supported by X15940; NM_000993 LOC390284 12 similar to signal recognition particle 14kDa (homologous Alu RNA binding protein); signal recognition particle 14kD (homologous Alu RNA-binding protein); signal recognition particle 14kD (homologous Alu RNA binding protein) TNFRSF7 12p13 tumor necrosis factor receptor superfamily, member 7 TAPBP-R 12p13.31 TAP binding protein related VAMP1 12p13.31-p13.2 vesicle-associated membrane protein 1 (synaptobrevin 1) PKP2P1 12p13 vesicle-associated membrane protein 1 (synaptobrevin 1) MRPL51 12p13.3-p13.1 mitochondrial ribosomal protein L51 CNAP1 12p13.3 chromosome condensation-related SMC-associated protein 1 GAPD 12p13.31 glyceraldehyde-3-phosphate dehydrogenase HOM-TES-103 12p13.3 HOM-TES-103 tumor antigen-like NOL1 12p13.31 nucleolar protein 1, 120kDa CHD4 12p13 chromodomain helicase DNA binding protein 4 GPR92 12p13.32 G protein-coupled receptor 92 ACRBP 12p13.32 acrosin binding protein ING4 12p13.32 inhibitor of growth family, member 4 ZNF384 12p12 zinc finger protein 384 DKFZp547D2210 12p13.31 hypothetical protein DKFZp547D2210
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2748 12.9 118 - 2008 18655825
4 - 3151 12.8 117 - 2008 18655825
variant 2 contains an additional segment in the 3' region compared to variant 1, leading to an isoform with a distinct C terminus compared to isoform 1
5 - 1104 12.7 116 - 2008 18655825
variant 3 contains an additional segment in the 3' region compared to variant 1, leading to an isoform with a distinct C terminus compared to isoform 1
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
Nervousbrainhindbrainponstrigeminal ganglia  Homo sapiens
 braindiencephalonthalamusnuclei  Homo sapiens
 nerve    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a V-SNARE coiled-coil homology domain
secondary structure one alpha helix contributing to the four helix bundle of synaptic SNARE complex
HOMOLOGY
interspecies ortholog to murine Vamp1
Homologene
FAMILY synaptobrevin family, V-SNARE protein
CATEGORY regulatory , structural protein , transport
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,outer
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic,vesicle
text
  • fusion of synaptic vesicles to target membranes
  • VAMP1 and VAMP2, both co-sediment and co-localize with NPPA
  • basic FUNCTION
  • soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein
  • calcium-dependent role in the docking and fusion of synaptic vesicles with the presynaptic membrane
  • playing a central role in neural exocytosis
  • its cleavage modifies the coupling between channels and release-competent vesicles
  • potentially having a vital role in a subset of central nervous system tissues
  • its structure is clearly controlled by protein-lipid interactions
  • with VAMP2, and syntaxin-4 regulate NPPA release from cardiac myocyte
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • constituent of a synaptic core complex with syntaxin and synaptosome associated proteins (SNAP25)
  • three SNAREs, STX4, VAMP1 and VAMP2, form a SNARE complex inside cardiac myocytes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to t-SNARES, syntaxin (STX) and SNAP25 after the fusion of synaptic vesicles to plasma membrane
  • interacting with VAPA and VAPB
  • interacting with BCAP29
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPAX1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS