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FLASH GENE

Symbol

VAMP1

contributors: mct - updated : 29-06-2013

HGNC name	vesicle-associated membrane protein 1 (synaptobrevin 1)
HGNC id	12642

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SPAX1 spastic ataxia 1
Location	12p13.31      Physical location : 6.571.405 - 6.579.843
Synonym symbol(s)	DKFZp686H12131, SYB1, VAMP-1

DNA

TYPE	functioning gene
STRUCTURE	8.44 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014231 5 - 2748 VAMP1A 12.9 118 - 2008 18655825 NM_199245 4 - 3151 VAMP1D 12.8 117 - 2008 18655825 variant 2 contains an additional segment in the 3' region compared to variant 1, leading to an isoform with a distinct C terminus compared to isoform 1 NM_016830 5 - 1104 VAMP1B 12.7 116 - 2008 18655825 variant 3 contains an additional segment in the 3' region compared to variant 1, leading to an isoform with a distinct C terminus compared to isoform 1

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea Corti   Homo sapiens Nervous brain hindbrain pons trigeminal ganglia   Homo sapiens   brain diencephalon thalamus nuclei   Homo sapiens   nerve

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Muscular striatum skeletal     Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a V-SNARE coiled-coil homology domain

secondary structure

one alpha helix contributing to the four helix bundle of synaptic SNARE complex

HOMOLOGY

interspecies

ortholog to murine Vamp1

Homologene

FAMILY

synaptobrevin family, V-SNARE protein

CATEGORY

regulatory , structural protein , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic,vesicle
text	fusion of synaptic vesicles to target membranes
	VAMP1 and VAMP2, both co-sediment and co-localize with NPPA

basic FUNCTION	soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein
	calcium-dependent role in the docking and fusion of synaptic vesicles with the presynaptic membrane
	playing a central role in neural exocytosis
	its cleavage modifies the coupling between channels and release-competent vesicles
	potentially having a vital role in a subset of central nervous system tissues
	its structure is clearly controlled by protein-lipid interactions
	with VAMP2, and syntaxin-4 regulate NPPA release from cardiac myocyte
	with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
	dual role of VAMP1, SNAP25, STX1A in exo- and endocytosis suggests that SNARE proteins may be molecular substrates contributing to the exocytosis-endocytosis coupling, which maintains exocytosis in secretory cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

exocytosis transport

PATHWAY

metabolism

signaling

neurotransmission

a component	constituent of a synaptic core complex with syntaxin and synaptosome associated proteins (SNAP25)
	three SNAREs, STX4, VAMP1 and VAMP2, form a SNARE complex inside cardiac myocytes

INTERACTION

DNA

RNA

small molecule

protein	binding to t-SNARES, syntaxin (STX) and SNAP25 after the fusion of synaptic vesicles to plasma membrane
	interacting with VAPA and VAPB
	interacting with BCAP29
	dual role of SNAP25 and VAMP1 in both exocytosis and slow endocytosis at conventional synapses

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPAX1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS