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FLASH GENE
Symbol MYH7 contributors: mct/npt - updated : 16-01-2018
HGNC name myosin, heavy chain 7, cardiac muscle, beta
HGNC id 7577
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a globular head (associating to the light chain and containing actin and ATP binding sites)
  • a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter) connected to the base of a long alpha helical tail,(the liver)
  • a light meromyosin domain of the myosin rod (LMM)important for thick filament assembly or for accessory protein binding
  • four coiled-coil regions of a sarcomeric myosin rod, and rod of sarcomeric myosins directs thick filament assembly and is characterized by the insertion of four skip residues that introduce discontinuities in the coiled-coil heptad repeats
    • secondary structure two heavy chains subunits (mhc), two alkali light chain subunits (mlc) and two regulatory light chain subunits (mlc2)
    HOMOLOGY
    interspecies homolog to murine Myhcb
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text sarcomeric protein
    basic FUNCTION
  • motor contractile protein moving towards the "plus" end of actin track
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MKX regulating the transcription of MYH7 through repression of SOX6 which predicts a role in fiber type specificity
  • MSTN positively regulates slow isoform MYH7 but negatively regulates fast isoforms MYH1, MYH4
  • FOXO1 has important roles in promoting diabetic cardiomyopathy and controls MYH7 expression in the development of cardiac dysfunction
    • cell & other
    REGULATION
    repressed by repressed by thyroid hormone (T3)
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1S , MPD1 , MMS , SPMM
    related resource FHC Mutation Database
    Susceptibility to idiopathic dilated cardiomyopathy
    Variant & Polymorphism other mutated in idiopathic dilated cardiomyopathy (Moller 2009)
    Candidate gene
    Marker
  • MYH7, IGFBP7, ANXA2, and DES are all excellent candidate plasma biomarkers of heart failure
    • Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquiredheart failure
    activation of myosin by omecamtiv mecarbil may provide a new therapeutic approach for systolic heart failure
    ANIMAL & CELL MODELS