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FLASH GENE

Symbol

MYH7

contributors: mct/npt - updated : 16-01-2018

HGNC name	myosin, heavy chain 7, cardiac muscle, beta
HGNC id	7577

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head, opposite orientation
text	head to head orientation with alpha cardiac myosin gene
STRUCTURE	22.92 kb     40 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see MYH6

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000257 40 - 6044 NP_000248 223 1935 - 1992 1301151

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive mouth tongue       Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a globular head (associating to the light chain and containing actin and ATP binding sites)
	a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter) connected to the base of a long alpha helical tail,(the liver)
	a light meromyosin domain of the myosin rod (LMM)important for thick filament assembly or for accessory protein binding
	four coiled-coil regions of a sarcomeric myosin rod, and rod of sarcomeric myosins directs thick filament assembly and is characterized by the insertion of four skip residues that introduce discontinuities in the coiled-coil heptad repeats

secondary structure

two heavy chains subunits (mhc), two alkali light chain subunits (mlc) and two regulatory light chain subunits (mlc2)

HOMOLOGY

interspecies

homolog to murine Myhcb

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	sarcomeric protein

basic FUNCTION

motor contractile protein moving towards the "plus" end of actin track

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MKX regulating the transcription of MYH7 through repression of SOX6 which predicts a role in fiber type specificity
	MSTN positively regulates slow isoform MYH7 but negatively regulates fast isoforms MYH1, MYH4
	FOXO1 has important roles in promoting diabetic cardiomyopathy and controls MYH7 expression in the development of cardiac dysfunction

cell & other

REGULATION

repressed by

repressed by thyroid hormone (T3)

ASSOCIATED DISORDERS

corresponding disease(s)

CMD1S , MPD1 , MMS , SPMM

related resource

FHC Mutation Database

Susceptibility

to idiopathic dilated cardiomyopathy

Variant & Polymorphism other	mutated in idiopathic dilated cardiomyopathy (Moller 2009)

Candidate gene
Marker	MYH7, IGFBP7, ANXA2, and DES are all excellent candidate plasma biomarkers of heart failure
Therapy target
	System Type Disorder Pubmed cardiovascular aquired heart failure activation of myosin by omecamtiv mecarbil may provide a new therapeutic approach for systolic heart failure

ANIMAL & CELL MODELS