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FLASH GENE

Symbol

MYH6

contributors: mct - updated : 03-06-2014

HGNC name	myosin, heavy chain 6, cardiac muscle, alpha
HGNC id	7576

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CMH6 , ASD3 , SSS3 , CMD1EE

Susceptibility

to variation of cardiac conduction

Variant & Polymorphism SNP	c.2161C>T missense mutation in MYH6 resulting in p.Arg721Trp associates with SSS3
	common variants in this gene modulate cardiac conduction affecting heart rate and the PR intervall

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired heart failure activation of myosin by omecamtiv mecarbil may provide a new therapeutic approach for systolic heart failure

ANIMAL & CELL MODELS