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FLASH GENE
Symbol MYH2 contributors: mct - updated : 12-05-2010
HGNC name myosin, heavy polypeptide 2, skeletal muscle, adult
HGNC id 7572
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • globular head associating to the light chain and containing actin and ATP binding sites
  • a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter)
  • a long alpha helical tail, (the liver)
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • motor contractile protein moving towards the "plus" end of actin track
  • role in glioma invasion of the brain (PMID
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by S100A4 (regulate MYH2 assembly by monomer sequestration, cell shape and motility through the modulation of its function)
    ASSOCIATED DISORDERS
    corresponding disease(s) IBM3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    importance of this molecular motor as a potential target for new anti-invasive therapies to treat malignant brain tumors
    ANIMAL & CELL MODELS