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FLASH GENE
Symbol MYH2 contributors: mct - updated : 12-05-2010
HGNC name myosin, heavy polypeptide 2, skeletal muscle, adult
HGNC id 7572
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
 pharynx   highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • globular head associating to the light chain and containing actin and ATP binding sites
  • a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter)
  • a long alpha helical tail, (the liver)
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • motor contractile protein moving towards the "plus" end of actin track
  • role in glioma invasion of the brain (PMID
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by S100A4 (regulate MYH2 assembly by monomer sequestration, cell shape and motility through the modulation of its function)
    ASSOCIATED DISORDERS
    corresponding disease(s) IBM3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    importance of this molecular motor as a potential target for new anti-invasive therapies to treat malignant brain tumors
    ANIMAL & CELL MODELS