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FLASH GENE

Symbol

MYH2

contributors: mct - updated : 12-05-2010

HGNC name	myosin, heavy polypeptide 2, skeletal muscle, adult
HGNC id	7572

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017534 40 - 6163 NP_060004 - 1941 - 1999 10077619 NM_001100112 40 - 6163 NP_001093582 - 1941 - 1999 10077619

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue         pharynx       highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	globular head associating to the light chain and containing actin and ATP binding sites
	a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter)
	a long alpha helical tail, (the liver)

HOMOLOGY

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,nucleolus

basic FUNCTION	motor contractile protein moving towards the "plus" end of actin track
	role in glioma invasion of the brain (PMID

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated by S100A4 (regulate MYH2 assembly by monomer sequestration, cell shape and motility through the modulation of its function)

ASSOCIATED DISORDERS

corresponding disease(s)

IBM3

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain   importance of this molecular motor as a potential target for new anti-invasive therapies to treat malignant brain tumors

ANIMAL & CELL MODELS