Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MYH2 contributors: mct - updated : 12-05-2010
HGNC name myosin, heavy polypeptide 2, skeletal muscle, adult
HGNC id 7572
Corresponding disease
IBM3 inclusion body myopathy 3
Location 17p13.1      Physical location : 10.424.468 - 10.453.017
Synonym name
  • myosin heavy chain IIa
  • myosin heavy chain, skeletal muscle, adult 2
  • Synonym symbol(s) MYH2A, MYHSA2, MYHas8, MyHC-2A, MyHC-IIa
    DNA
    TYPE functioning gene
    STRUCTURE 28.55 kb     40 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see MYH1
    Physical map
    FLJ32734 17p13.1 hypothetical protein FLJ32734 LOC388333 17 similar to Williams-Beuren syndrome critical region protein 19 FLJ35773 17p13.1 hypothetical protein FLJ35773 P101-PI3K 17p13.1 phosphoinositide-3-kinase, regulatory subunit, polypeptide p101 LOC388334 17 LOC388334 NTN1 17p13-p12 netrin 1 STX8 17p12 syntaxin 8 LOC146845 17p13.1 hypothetical protein LOC146845 USP43 17p12 ubiquitin specific protease 43 LOC201140 17p13.1 similar to DKFZP566O084 protein GLP2R 17p13.3 glucagon-like peptide 2 receptor RCV1 17p13.2 recoverin GAS7 17p13 growth arrest-specific 7 RPS27AP1 17 ribosomal protein S27a pseudogene 1 MYH13 17p13.1-p12 myosin, heavy polypeptide 13, skeletal muscle MYH8 17p13.1 myosin, heavy polypeptide 8, skeletal muscle, perinatal MYH4 17p13.1 myosin, heavy polypeptide 4, skeletal muscle MYH1 17p13.1 myosin, heavy polypeptide 1, skeletal muscle, adult MYH2 17p13.1 myosin, heavy polypeptide 2, skeletal muscle, adult MYH3 17p13.1 myosin, heavy polypeptide 3, skeletal muscle, embryonic SCO1 17p13-p12 SCO cytochrome oxidase deficient homolog 1 (yeast) MDS006 17p13.1 x 006 protein LOC388335 17 similar to RIKEN cDNA A730055C05 gene LOC388336 17 similar to hypothetical protein D430041B17 LOC284033 17p13.1 hypothetical protein LOC284033 DNAH9 17p12 dynein, axonemal, heavy polypeptide 9 ZNF18 17p13-p12 zinc finger protein 18 (KOX 11) LOC390763 17 similar to 60S ribosomal protein L21 MAP2K4 17p11.2 mitogen-activated protein kinase kinase 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    40 - 6163 - 1941 - 1999 10077619
    40 - 6163 - 1941 - 1999 10077619
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
     pharynx   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • globular head associating to the light chain and containing actin and ATP binding sites
  • a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter)
  • a long alpha helical tail, (the liver)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • motor contractile protein moving towards the "plus" end of actin track
  • role in glioma invasion of the brain (PMID
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by S100A4 (regulate MYH2 assembly by monomer sequestration, cell shape and motility through the modulation of its function)
    ASSOCIATED DISORDERS
    corresponding disease(s) IBM3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    importance of this molecular motor as a potential target for new anti-invasive therapies to treat malignant brain tumors
    ANIMAL & CELL MODELS