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FLASH GENE

Symbol

MYCL1

contributors: mct - updated : 20-03-2012

HGNC name	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
HGNC id	7555

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001033081 2 splicing polyA site 3624 NP_001028253 39.2 364 - Kaye NM_001033082 3 splicing polyA site 3260 NP_001028254 - 394 - Kaye, Kambara NM_005376 2 - 2050 NP_005367 - 236 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain       moderately Respiratory respiratory tract larynx

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

basic helix-loop-helix (HLH), leucine zipper domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to avian myelocytomatosis viral (v-myc) oncogene 1
	ortholog to murine Lmyc1
	homolog to C.elegans Y75B8A.28

Homologene

FAMILY	basic helix-loop-helix (BHLH) family of transcription factors
	BHLH-ZIP subfamily

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	as well as MYC mutants (W136E and dN2), all of which have little transformation activity, promoted human induced pluripotent stem cells (iPSC) generation more efficiently and specifically compared with MYC

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimerizing with MAX

INTERACTION

DNA	binds DNA as an
	heterodimer with MAX

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in colorectal tumor with poor prognosis tumoral   amplification     in Merkel cell carcinoma

Susceptibility

to head and neck nonmelanoma skin (HNNMSC)

Variant & Polymorphism other	SS genotype was found to correlate with aggressive tumor behavior in patients with HNNMSC and a family history of cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS