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FLASH GENE
Symbol MUC2 contributors: mct/npt - updated : 11-06-2008
HGNC name mucin 2, oligomeric mucus/gel-forming
HGNC id 7512
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extended array of tandem repeats flanked by cysteine-rich subdomains
  • cystine Knot domain (at C terminus)
  • two VWF type D domain
    • conjugated GlycoP
    mono polymer polymer
    HOMOLOGY
    interspecies homolog to murine Muc2
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in epithelial cell differentiation
  • coating the epithelia of the intestines, airways and other mucus membrane containing organs, against particles and infections agents
  • contribute in mucus formation by forming a tridimensional network via oligomerization domains to protect underlying epithelia against diverse injuries
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • glycoprotein constituent of membrane
  • main protein component of intestinal mucus
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by FOXA1, FOXA2
    regulated by histone H3 modification and DNA methylation in pancreatic cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in epithelial ovarian cancer and in bladder cancer
    tumoral     --other  
    aberrant MUC2 expression in intestinal cancers and other intestinal disorders
    tumoral     --other  
    expression pattern of secreted mucins including MUC2 and MUC6 is altered apparently in gastric carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS