Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MUC1 contributors: mct - updated : 17-06-2017
HGNC name mucin 1, cell surface associated
HGNC id 7508
ASSOCIATED DISORDERS
corresponding disease(s) MCKD1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in esophageal squamous-cell carcinoma with poor prognosis
tumoral     --over  
in endometrial adenocarcinomas
tumoral     --over  
in hepatocellular and cholangiocarcinoma
constitutional     --over  
in severe preeclamptic placentas and MUC1 overexpression suppresses extravillous trophoblast (EVT) invasion mainly via modulating beta1-integrin signaling (
tumoral     --over  
in up to 90 p100 of breast carcinomas
tumoral     --other  
expression of aberrantly glycosylated Mucin-1 in ovarian cancer
tumoral     --over  
aberrantly overexpressed in human breast cancer and other cancers
tumoral     --over  
in several carcinomas including pancreatic adenocarcinoma
Susceptibility to the development of intestinal metaplasia preceding gastric carcinoma
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
inhibition of MUC1-C represents a potential therapeutic approach to induce terminal differentiation of acute myelogenous leukemia cells
cancerlung 
could be an effective target for the treatment of lung cancer.
cancerdigestiveoesophagus
MUC1 and MUC4 may be attractive targets for the selection of treatment methods in oral squamous cell carcinoma (OSCC)
ANIMAL & CELL MODELS