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FLASH GENE

Symbol

MT2A

contributors: mct/npt - updated : 22-10-2015

HGNC name	metallothionein 2A
HGNC id	7406

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function significantly down-regulated in proliferating keloid fibroblast (KF) constitutional     --over   MT1A/MT2A expression was increased in hippocampi from temporal lobe epilepsy (TLE) patients tumoral     --low   downregulated in colon cancer tissue

Susceptibility

to coronary heart disease (CHD) to metal toxicity

Variant & Polymorphism SNP	polymorphism of MT2A-838G/C is correlated to CHD, and the C allele might be a CHD-susceptible gene and might also have an effect on the extent of coronary artery disease
	the 5-GG genotype individuals may be more sensitive for the metal toxicity and they should be more careful about protecting their health against the toxic effects of the heavy metals

Candidate gene
Marker	levels of MT1F and MT2A mRNA could be considered as new markers of poor prognosis of non-small cell lung cancer patients
Therapy target

ANIMAL & CELL MODELS