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FLASH GENE
Symbol TSG1A contributors: npt - updated : 17-03-2006
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains TP73 protein (TP73)
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • tumor suppressor gene(s)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral imprinting      
    maternal imprinting of MYCN amplified neuroblastoma
    tumoral   LOH    
    in nasopharyngeal carcinoma, neuroblastoma, cervical carcinoma, Merkel cell carcinoma, oligodendroglioma, oligoastrocytoma, meningioma, breast cancer, colon carcinoma, Wilms tumor, squamous cell carcinoma of the oral cavity
    tumoral   deletion    
    in neuroblastoma, oligodendroglioma, glioma, Merkel cell carcinoma, anaplastic meningiomas
    tumoral   translocation    
    in malignant melanoma, neuroblastoma
    tumoral        
    duplicated in neuroblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS