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FLASH GENE
Symbol RAB4A contributors: mct/npt/pgu - updated : 27-01-2017
HGNC name RAB4A, member RAS oncogene family
HGNC id 9781
Location 1q42.13      Physical location : 229.406.878 - 229.440.517
Synonym name oncogene RAB4
Synonym symbol(s) RAB4, HRES-1/RAB4, HRES-1
DNA
TYPE functioning gene
STRUCTURE 34.83 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TRIM11 1q42.13 tripartite motif-containing 11 TRIM17 1q42 tripartite motif-containing 17 HIST3H3 1q42 histone 3, H3 LOC391175 1 similar to 60S ribosomal protein L23a HIST3H2A 1q42.13 histone 3, H2a HIST3H2BB 1q42.13 histone 3, H2bb HIST3H2BA 1 histone 3, H2ba LOC149603 1q42.13 hypothetical protein LOC149603 FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751 RAB4A 1q42-q43 RAB4A, member RAS oncogene family SPHAR 1q42.11-q42.3 S-phase response (cyclin-related) LOC126731 1q42.13 LOC126731 ACTA1 1q42.13-q42.2 actin, alpha 1, skeletal muscle NUP133 1q42.13 nucleoporin 133kDa ABCB10 1q42 ATP-binding cassette, sub-family B (MDR/TAP), member 10 TAF5L 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa KIAA0133 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC391177 1 similar to HMG-1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3056 - 218 - 2009 19302266
6 - 2822 - 113 human fibroblast cell lineage 1989 2501306
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Reproductivefemale systemuteruscervix highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage fibroblast cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , PhosphoP
HOMOLOGY
interspecies homolog to murine Rab4a
homolog to yeast S.cerevisiae Ypt1 and sec4
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY protooncogene , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • is localized to early and recycling endosomes and is required for the rapid recycling of receptors from early endosomes to the cell surface
  • membrane-associated and cytoplasmic when phophorylated by CDC2 kinase during mitosis
  • basic FUNCTION
  • GTPase
  • regulating vesicular transport pathways
  • regulating intracellular transport
  • may be involved in vesicular trafficking
  • playing a role n recylcing from early endosomes to the plasma membrane
  • via its interaction with RUFY1, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
  • participates in adherens junction dynamics in tetis
  • play an essential role in the control of the glucose transporterSLC2A4 trafficking, which is essential for insulin-mediated glucose uptake
  • regulating a recycling pathway that is a critical effector of FLT1 during branching morphogenesis of the vasculature
  • RAB14 and RAB4 regulate endosomal functions through cooperative interactions with their dual effector, RUFY1
  • RAB4A and RAB5A GTPases are key players in the regulation of endocytosis
  • is a master regulator of receptor recycling from endocytic compartments to the plasma membrane
  • mitochondrial turnover involves endosomal traffic regulated by RAB4A, a small GTPase that is overexpressed in lupus T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP binding
  • protein
  • interacting with RUFY1, a RAB4A effector involved in early endosomal traffic
  • down- or up-regulation of RAB4A expression or RAB4A function triggered inhibition or increase of CTSL secretion respectively
  • evolutionarily conserved function of PTPN23-RAB4A in the regulation of endocytic trafficking, cell adhesion and migration
  • TBC1D16 interferes with RAB4A-mediated EGFR recycling, thereby promoting its degradation
  • RAB4A decreases the KCNH2 density at the plasma membrane by increasing the endogenous NEDD4L expression
  • ARL1 links RAB4A-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery
  • RABEP1 is recruited by both RABGEF1 recognizing ubiquitylated cargo and by RAB4A to activate RAB5A in a feed-forward manner
  • cell & other
    REGULATION
    inhibited by phopshorylation by CDC2 kinase during mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    laminar shear stress upregulated RAB4A expression, which contributed to improved EC autophagy and function
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS